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Molecular Landscape of Non-Muscle Invasive Bladder Cancer.

Joshua J Meeks, Seth P Lerner
Cancer Cell 2017 November 14
In this issue of Cancer Cell, Hurst et al. report an integrated analysis of non-invasive (stage Ta) bladder cancer. Two genomic subtypes are distinguished by chromosome 9q loss, resulting in increased AKT/PI3K/mTOR signaling. Tumors from female patients have a higher frequency of KDM6A mutations.

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