Add like
Add dislike
Add to saved papers

Plasma Interleukin-1β (IL-1β) Concentrations at the Different Phases of the Oestrus Cycle in Clomiphene Treated Female Rats.

Interleukin - 1β (IL-1β) is a signal molecule known for its role in inflammation and immune response. However,there are reports on the possible effects of IL-1β in ovulation and various aspects on female reproduction. It was thereforenecessary to determine plasma IL-1β levels in female rats administered ovulation inducing agent clomiphene citrate. In thiswork, a total of forty (40) female wistar rats weighing between 150g and 225g were used. Twenty of the rats wereadministered 0.14mg/kg clomiphene citrate orally daily for five days while the other twenty which served as control, receivednormal saline. The phases of the oestrus cycle (proestrus, estrus, metestrus and diestrus) were determined between the hoursof 8.30am and 10.00am on the sixth day prior to collection of blood sample by cardiac puncture. The plasma IL-1βconcentrations were determined using rat IL-1β ELISA kits. From the experiment, 41.2% of the control rats were in thediestrus phase while 42.1% of the clomiphene citrate treated rats were in the estrus phase. The IL-1β plasma concentrationswere higher in clomiphene treated rats at all the phases of the oestrus cycle of experimental rats when compared with thecontrol. The increase in plasma IL-1β was significant (p˂0.05) in the estrus phase of the clomiphene citrate treated rats(550.53pg/ml) when compared with the control (304.42pg/ml). The high plasma concentration of IL-1β at the estrus phaseof clomiphene citrate treated rats suggests its possible involvement in oocyte maturation and ovulation which characterizesthe phase.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app