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Flow Cytometric Evaluation of Primary Immunodeficiencies.

Andreas Boldt, Michael Bitar, Ulrich Sack
Clinics in Laboratory Medicine 2017 December
Primary immunodeficiency diseases are genetic disorders that mostly cause susceptibility to infections and are sometimes associated with autoimmune and malignant diseases. For early detection and management of these diseases, flow cytometric procedures allow an encompassing assessment of cellular phenotypes and cellular functions. State-of-the art cytometry is based today on 8- to 10-color staining and includes an assessment of lineage maturation and functional markers.

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