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COMMENT
JOURNAL ARTICLE
REVIEW
Evidence for Converging DNA Methylation Pathways in Placenta and Cancer.
Developmental Cell 2017 November 7
CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced methylome in early extraembryonic tissues resembles that of many cancers, suggesting that placental nuclear programming might be co-opted in tumorigenesis.
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