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Dual-target cancer theranostic for glutathione S-transferase and hypoxia-inducible factor-1α inhibition.
Chemical Communications : Chem Comm 2017 November 17
We developed a dual-target theranostic F671 , which could exhibit synergetic anticancer effects for inhibiting the activities of glutathione S-transferase and the accumulation of hypoxia inducible factor-1α. F671 undergoes self-immolative cleavage when exposed to GSTP1-1 in live cancer cells, facilitating the visualization of molecule release and distribution, as well as confirming the autophagy-induced apoptosis.
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