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Synthesis, structure and in vitro cytotoxicity of platinum(II) complexes containing eugenol and a quinolin-8-ol-derived chelator.
Acta Crystallographica. Section C, Structural Chemistry 2017 November 2
The synthesis of potassium (η2 -4-allyl-2-methoxyphenol)trichloridoplatinate(II), K[PtCl3 (C10 H12 O2 )], (1), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from (1), three new platinum(II) complexes, namely (η2 -4-allyl-2-methoxyphenol)chlorido(2-methylquinolin-8-olato-κ2 N,O)platinum(II), (2), (η2 -4-allyl-2-methoxyphenol)chlorido(5-nitroquinolin-8-olato-κ2 N,O)platinum(II), (3), and (η2 -4-allyl-2-methoxyphenol)chlorido(5,7-dichloroquinolin-8-olato-κ2 N,O)platinum(II), [Pt(C9 H4 Cl2 NO)Cl(C10 H12 O2 )], (4), containing eugenol and a quinolin-8-ol derivative (R-OQ), have been synthesized and characterized by elemental analyses, MS, IR, 1 H NMR and NOESY spectra. For (1) and (4), single-crystal X-ray diffraction studies were also carried out. Complexes (2)-(4) show good inhibiting abilities on three human cancer cell lines, i.e. KB, Hep-G2 and LU, with IC50 values of 1.42-17.8 µM. Complex (3) gives an impressively high activity against KB, Hep-G2, LU and MCF-7, with IC50 values of 1.42-4.91 µM, which are much lower than those of cisplatin and some other platinum(II) complexes.
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