We have located links that may give you full text access.
Surface Modified Ti 3 C 2 MXene Nanosheets for Tumor Targeting Photothermal/Photodynamic/Chemo Synergistic Therapy.
ACS Applied Materials & Interfaces 2017 November 23
Ti3 C2 MXene is a new two-dimensional material exhibiting a variety of novel properties including good photothermal effect, and the capability of Ti3 C2 for multimodal tumor therapy is in urgent need of development. Herein, ultrathin Ti3 C2 MXene nanosheets (∼100 nm) have been synthesized by supplying additive Al3+ to avoid Al loss and employed as a photothermal/photodynamic agent for cancer therapy. The as-obtained nanosheets exhibit outstanding mass extinction coefficient (28.6 Lg-1 cm-1 at 808 nm), superior photothermal conversion efficiency (∼58.3%), and effective singlet oxygen generation (1 O2 ) upon 808 nm laser irradiation. Based on these Ti3 C2 nanosheets, a multifunctional nanoplatform (Ti3 C2 -DOX) is established via layer-by-layer surface modification with doxorubicin (DOX) and hyaluronic acid (HA). In vitro and in vivo experiments disclose that Ti3 C2 -DOX shows enhanced biocompatibility, tumor specific accumulation, and stimuli-responsive drug release behavior and achieve effective cancer cell killing and tumor tissue destruction through photothermal/photodynamic/chemo synergistic therapy.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app