JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

[Update on recent progress in vitamin D research. Vitamin D receptor and the nuclear receptor superfamily.]

The vitamin D receptor(VDR)is a ligand-dependent transcription factor of the nuclear receptor superfamily. VDR belongs to the NR1I subfamily along with other nuclear receptors involved in xenobiotic metabolism, such as pregnane X receptor. The oxysterol receptors liver X receptors α/β and the bile acid receptor farnesoid X receptor belong to the NR1H subfamily, which are closely related to the NR1I subfamily. NR1I and NR1H nuclear receptors form heterodimers with retinoid X receptor. The active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], acts as a physiological VDR ligand, and regulates various physiological processes, including calcium and bone metabolism, cellular growth and differentiation, immunity, and cardiovascular function. The secondary bile acid lithocholic acid, which is produced by intestinal bacteria, is another natural VDR ligand. Lithocholic acid stimulates xenobiotic metabolism and regulates immune and inflammatory responses via VDR, and its calcemic action is limited and observed only in vitamin D-deficient animals. Thus, lithocholic acid may be a function-selective VDR ligand. VDR is a promising drug in the treatment of bone and mineral disorders, cancer, autoimmune disease, inflammation, and cardiovascular disease. However, the adverse effect hypercalcemia limits wider clinical application of 1,25(OH)2 D3 and its derivatives. Elucidation of the mechanism of VDR function by lithocholic acid should expand the possibility of VDR-targeted approaches.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app