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Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!

Luisa Robbez-Masson, Christopher H C Tie, Helen M Rowe
Journal of Cell Biology 2017 November 7
Cancer cells thrive on genetic and epigenetic changes that confer a selective advantage but also need strategies to avoid immune recognition. In this issue, Cuellar et al. (2017. J. Cell Biol https://doi.org/10.1083/jcb.201612160) find that the histone methyltransferase SETDB1 enables acute myeloid leukemia cells to evade sensing of retrotransposons by innate immune receptors.

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