Decreased variability of dynamic phase synchronization in brain networks during hand movement.

Dynamic functional connectivity analysis, a rapidly growing method, has been demonstrated to provide new spatiotemporal information about how brain motor network would reorganize from rest to motor tasks. Phase synchronization analysis, which has been widely applied in EEG-based FC analysis, is a promising alternative method in dynamic FC analysis. In this study, fMRI data were recorded from 28 healthy volunteers when they are resting and performing hand closing and opening (HCO) task. Dynamic FC was estimated by phase synchronization analysis. In addition, functional connectivity variability (FCV) was compared between rest and HCO to investigate the modulation induced by motor task on dynamics of motor-related FC and network. Results showed that the FCVs in network-of-interest, including default-mode network and motor network, decreased during HCO comparing with rest. Our results demonstrated that the unconstrained mental activities, which resulted in high FCV during rest, would focus on motor execution during HCO and thus led to decreased FCV during HCO.