Assessment of rehabilitation potential in patients with vascular dysfunction caused by undifferentiated connective tissue dysplasia.

INTRODUCTION: Degradation of collagen, inherent to undifferentiated connective tissue dysplasia (UCTD) syndrome, also influences the changes in the structure of vascular walls. This contributes to the development of configured vascular anomalies, which are an independent predictor of vascular accident risk. Such diversity of UCTD manifestations requires development of prognostic criteria for rehabilitation potential, correction of which may contribute to recovery process in case of development of vascular catastrophe. Study aim is to evaluate the rehabilitation potential in patients with vascular dysfunction and underlying UCTD.

MATERIALS AND METHODS: The study involved 150 male patients with confirmed diagnosis of UCTD (average age - 26.4 ± 0.6 years). All patients had a complex clinical and instrumental examination. Phenotypic and UCTD visceral stigmas, UCTD biochemical markers were analyzed, followed by statistical processing of the results by method of variotional statistics.

RESULTS: We revealed the high degree of direct correlation between the presence of vascular dysfunction and myxomatous degeneration of the mitral valve (r = + 0.76, p.