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Taming photo-induced oxidation degradation of dihydropyridine drugs through cocrystallization.
Chemical Communications : Chem Comm 2017 November 15
Cocrystallization of nifedipine (NFD) and isonicotinamide (INA) resulted in two monotropic cocrystal polymorphs. The thermodynamically more stable polymorph presents superior photostability compared to the other. Cocrystallization can be an efficient approach to address the stability deficit of dihydropyridine drugs.
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