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Journal Article
Review
Ependymomas arising outside of the central nervous system: A case series and literature review.
Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia 2018 January
BACKGROUND: Extracranial and extraspinal ependymomas are extremely rare tumors mostly published in the literature as case reports.
METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.
RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.
CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
METHODS: MD Anderson Cancer Center institutional database was screened for patients with extra CNS ependymomas over a 25 year period.
RESULTS: Eight patients with extra CNS ependymoma were identified. Five cases originated in the sacrum or subcutaneous sacral area, and the other 3 cases originating in the breast, lung and adnexa of the uterus. By histology, most cases were myxopapillary ependymomas (5 cases), 2 cases were grade II ependymoma and 1 case was an anaplastic ependymoma. Metastases occurred in 6 cases and 3 patients died due to progressive disease. Most cases required surgery, radiation and chemotherapy.
CONCLUSION: Extra CNS ependymomas are very rare tumors that tend to metastasize, even though most cases are histologically classified as low grade ependymomas.
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