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Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential.
Chemical Communications : Chem Comm 2017 October 32
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.
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