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Synthesis of 4 H -Benzo[ e ][ 1,3 ]oxazin-4-ones by a Carbonylation-Cyclization Domino Reaction of ortho -Halophenols and Cyanamide.
ChemistryOpen 2017 October
A mild and convenient one-step preparation of 4 H -1,3-benzoxazin-4-ones by a domino carbonylation-cyclization process is developed. Readily available ortho -iodophenols are subjected to palladium-catalyzed carbonylative coupling with Mo(CO)6 and cyanamide, followed by a spontaneous, intramolecular cyclization to afford 4 H -1,3-benzoxazin-4-ones in moderate to excellent yields. Furthermore, the scope of the reaction is extended to include challenging ortho -bromophenols. Finally, to highlight the versatility of the developed method, Mo(CO)6 is successfully replaced with a wide array of CO-releasing reagents, such as oxalyl chloride, phenyl formate, 9-methylfluorene-9-carbonyl chloride, and formic acid, making this an appealing strategy for the synthesis of 4 H -benzo[ e ][ 1,3 ]oxazin-4-ones.
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