[Correlation of fetuin-B concentrations in serum and follicular fluid with outcomes of in vitro fertilization].

OBJECTIVE: To investigate the relationship between serum/follicular fluid fetuin B levels and outcome of in vitro fertilization (IVF).

METHODS: Infertility women (28 with low fertilization rates, 44 with normal fertilization rates) receiving IVF in Women's Hospital of Zhejiang University School of Medicine during June and December 2016 were enrolled in the study. Serum/follicular fluid fetuin B levels were measured with ELISA method. Correlations of serum and follicular fetuin B level with fertilization outcome of IVF were analyzed with Pearson correlation coefficient and receiver operating characteristic (ROC) curve.

RESULTS: A positive correlation between serum fetuin B and follicular fluid fetuin B levels was observed ( r =0.675, P <0.01). Both serum and follicular fluid fetuin B levels in women with low fertilization rates of IVF were lower than those in women with normal fertilization rates[(6.09±1.31) μg/mL vs. (7.13±1.47) μg/mL, t =3.050, P <0.05; (5.13±0.96)μg/mL vs. (6.22±1.33) μg/mL, t =3.755, P <0.01]. ROC analysis showed that the area under curve (AUC) of serum fetuin B level in predicting fertilization rate was 0.832 (95% CI :0.729-0.934, P <0.01), and 6.08 μg/mL could be used as cut-off value.

CONCLUSIONS: Serum fetuin B level is correlated with follicular fluid fetuin B level, and it may be used for predicting the fertilization outcome of IVF.