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Targeted tumor SPECT/CT dual mode imaging using multifunctional RGD-modified low generation dendrimer-entrapped gold nanoparticles.

Xiaoying Xu, Lingzhou Zhao, Xin Li, Peng Wang, Jinhua Zhao, Xiangyang Shi, Mingwu Shen
Biomaterials Science 2017 November 22
Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine-glycine-aspartic peptide and labeled with 99m Tc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αv β3 integrin-expressing tumors.

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