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Novel activity-based probes for N-acylethanolamine acid amidase.

Rita Petracca, Elisa Romeo, Marc P Baggelaar, Marta Artola, Silvia Pontis, Stefano Ponzano, Herman S Overkleeft, Mario van der Stelt, Daniele Piomelli
Chemical Communications : Chem Comm 2017 August 23
The cysteine hydrolase, N-acylethanolamine acid amidase (NAAA) is a promising target for analgesic and anti-inflammatory drugs. Here, we describe the development of two unprecedented NAAA-reactive activity-based probes as research tools for application in the discovery of new inhibitors and for the in-depth characterization of NAAA in its cellular environment.

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