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Clinical Trial, Phase II
Journal Article
Occurrence and significance of morphologic changes in patients with metastatic triple negative breast cancer treated with Cabozantinib.
Clinical Imaging 2018 March
OBJECTIVE: To compare performance of RECIST1.1 and Choi criteria in assessment of patients with metastatic triple-negative breast cancer treated with cabozantinib.
METHODS: Thirty patients with metastatic triple-negative breast cancer enrolled in phase 2 clinical trial received cabozantinib. Clinical benefit rates assessed by prospectively determined RECIST1.1 and retrospectively assessed Choi criteria were compared.
RESULTS: Decreased tumor density (≥15%) at first follow-up was seen in 22/30(73%) patients. CBR was 40% (95%CI:23-59%) by RECIST1.1, and 73% (95%CI:54-88%) by Choi (NPV=100%, 95%CI:63-100%; PPV=55%, 95%CI:32-76%).
CONCLUSIONS: Morphologic changes are seen in the majority of patients treated with cabozantinib, making Choi criteria valuable in response assessment.
METHODS: Thirty patients with metastatic triple-negative breast cancer enrolled in phase 2 clinical trial received cabozantinib. Clinical benefit rates assessed by prospectively determined RECIST1.1 and retrospectively assessed Choi criteria were compared.
RESULTS: Decreased tumor density (≥15%) at first follow-up was seen in 22/30(73%) patients. CBR was 40% (95%CI:23-59%) by RECIST1.1, and 73% (95%CI:54-88%) by Choi (NPV=100%, 95%CI:63-100%; PPV=55%, 95%CI:32-76%).
CONCLUSIONS: Morphologic changes are seen in the majority of patients treated with cabozantinib, making Choi criteria valuable in response assessment.
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