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A rare case of CD1a-negative Langerhans cell histiocytosis of the central nervous system in a child.
Clinical Case Reports 2017 October
Langerhans cell histiocytosis is a dendritic cell disorder with a wide spectrum of severity and presentations. Histopathology typically demonstrates a proliferation of Langerhans cells and a lymphohistiocytic inflammatory infiltrate with eosinophils. The diagnosis is supported by immunohistochemistry with the cell markers S100, CD1a, CD68, and Langerin [ Blood , 126, 2015, 26 and N Engl J Med , 331, 1994, 154].
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