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Pupillary light reflex and circadian synchronization in the elderly.

PsyCh Journal 2017 December
Most elderly lack a synchronized circadian rhythm and often cannot benefit from light therapy. Non-visual effects of light are mediated through intrinsic photosensitive retinal ganglion cells (ipRGCs). With chromatic pupillometry, the functionality of ipRGCs and their functional circuit in the brain can be tested.

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