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Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles.
MedChemComm 2017 May 2
A series of prenyl 1,2,3-triazoles were prepared from isoprenyl azides and different alkynes. The dipolar cycloaddition reaction provided exclusively primary azide products as regioisomeric mixtures that were separated by column chromatography and fully characterized. Most of the compounds displayed antiparasitic activity against Trypanosoma cruzi and Leishmania donovani . The most active compounds were assayed as potential Tc CYP51 inhibitors.
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