In Vitro Activities of Pexiganan and 10 Comparator Antimicrobials against 502 Anaerobic Isolates Recovered from Skin and Skin Structure Infections.

Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. The MIC90 s of studied isolates were as follows: Bacteroides fragilis , 16 μg/ml; other B. fragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; Porphyromonas spp., 64 μg/ml; Propionibacterium acnes , 4 μg/ml; Eggerthella lenta and Peptostreptococcus anaerobius , 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens , 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for skin and skin structure infections (SSSIs) involving anaerobes.