Customized Corneal Cross-linking Using Different UVA Beam Profiles.

PURPOSE: To evaluate the performance of different customized corneal cross-linking (CXL) methods.

METHODS: This was a single-center interventional, prospective, longitudinal case series. Four different customized CXL methods were evaluated in keratoconic eyes: (1) uniform (uniform intensity ultraviolet-A [UVA] beam [9 mW/cm2 ] for 10 minutes) (n = 12 eyes); (2) sector axial map (sector-based UVA irradiation) (n = 12 eyes); (3) ring axial map (concentric rings of UVA beam intensity centered at the steepest curvature of the anterior axial map) (n = 12 eyes); and ring tangential map (same as the ring axial map but centered at the steepest curvature of the anterior tangential map) (n = 14 eyes). Peak UVA energy density in the sector and ring axial map (and ring tangential map) protocols did not exceed 15.0 and 10.8 J/cm2 , respectively. A 0.1% riboflavin solution was applied after epithelium removal. Corneal tomography and visual acuity were assessed before and 6 months after CXL.

RESULTS: Average and peak energy density was lowest in the ring tangential protocol and highest in the sector axial map group (P < .001). Treated area was lowest in the ring tangential map group and highest in the uniform group (P < .001). Decrease in curvature was similar among the uniform, sector axial map, and ring axial map groups (P < .05). The ring tangential map group had the greatest decrease in curvature per unit energy dose to the cornea (P < .05). Improvement in uncorrected (0.081 ± 0.056 logMAR) and corrected (0.041 ± 0.026 logMAR) distance visual acuity per unit energy density was greatest in the ring tangential map group (P > .05).

CONCLUSIONS: When normalized to the average energy density, the ring tangential map protocol appeared to provide maximum flattening and improvement in visual acuity. Further studies with larger sample sizes are needed to validate the findings of this pilot study. [J Refract Surg. 2017;33(10):676-682.].