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Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences.
Chemical Communications : Chem Comm 2017 October 20
G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide sequence drastically increases the probability of forming tetramolecular parallel G4s with unprecedented conformational control over other unspecific oligomers or folds.
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