Fabrication and Physicochemical Investigation of Ancient Iranian and Pakistani Treated Silver Particles and their Comparison with Silver Nanoparticles.

Silver compounds are known to be both toxic and carcinogenic. However, silver nanoparticles have been showed diagnostic and therapeutic value. They can be used as biological tags for a quantitative detection and/or be incorporated into wound dressings and cosmetics due to their antibacterial properties. Pakistani and Iranian traditional physicians still take the advantage of silver compounds, called silver Kushta, to treat dementia, leprosy, and skin cancers. The present study compared the physicochemical properties of silver nanoparticles (AgNPs) and silver Kushtas (Pakistani silver Kushta (PKAg) and Iranian silver) in terms of the morphology, silver content, chemical composition, and suspension stability. AgNPs were produced through a chemical reduction method using AgNO3 and NaBH4 at 4 °C. PKAg powder was purchased from Hamdard pharmaceutical company (Pakistan). IKAg powder was produced, using closed reactor (Aghili method). Physicochemical properties of all three compounds were examined by scanning electron microscopy, dynamic light scattering, Fourier transform infrared, UV spectra Analysis, Energy Dispersive X-ray analysis, and X-ray diffraction. AgNPs were spherical-shaped and uniform in size. However, PKAg and IKAg particles show different sizes. Not only AgNPs but also IKAg & PKAg Particle sizes were less than 200 nm. According to EDX analysis, the silver contents of PKAg, IKAg, and were 66.24%, 50.43%, respectively. AgNPs, IKAg, and PKAg showed zeta potential values equal to -18.5 and -2.27, and -12 mV, successively. AgNPs, IKAg and PKAg sizes were 64.08, 190.4 and 51.72 nm, respectively. Moreover, XRD results indicated that the composition of IKAg and PKAg are completely different.