A new small-molecule KRE2 inhibitor against invasive Candida parapsilosis infection.

Tânia P Salci, Melyssa Negri, Ana Karina R Abadio, P Bonfim-Mendonça, Isis Capoci, Silvana M Caparroz-Assef, Lucélia Donatti, Maria Sueli S Felipe, Erika S Kioshima, Terezinha Ie Svidzinski

Future Microbiology 2017 November

AIM: To investigate the antifungal activity of MOL3, a small molecule that was selected by virtual screening, against Candida spp.

MATERIALS & METHODS: The antifungal activity of MOL3 was evaluated using standard strains and clinical isolates. Activity was evaluated in both in vitro tests and animal models.

RESULTS: The minimum fungicidal concentration of MOL3 against Candida spp. ranged from 16 to 128 mg/l. MOL3 at the sub-minimum fungicidal concentration inhibited hyphal elongation. The remaining yeast cells presented morphological changes and were metabolically inactive. MOL3 was toxicologically inert both in vitro and in the animal model. MOL3 also reduced experimental systemic infection by C. parapsilosis in mice.

CONCLUSION: The selection of MOL3 by virtual screening was successful, revealing a promising antifungal candidate.

Full text links

We have located links that may give you full text access.

Show additional links to paperHide additional links to paper

PubMed

Add to Saved Papers

Get 1-tap access

Related Resources

For the best experience, use the Read mobile app

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app