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Entorhinal and transentorhinal atrophy in mild cognitive impairment using longitudinal diffeomorphometry.

INTRODUCTION: Autopsy findings have shown the entorhinal cortex and transentorhinal cortex are among the earliest sites of accumulation of pathology in patients developing Alzheimer's disease.

METHODS: Here, we study this region in subjects with mild cognitive impairment ( n  = 36) and in control subjects ( n  = 16). The cortical areas are manually segmented, and local volume and shape changes are quantified using diffeomorphometry, including a novel mapping procedure that reduces variability in anatomic definitions over time.

RESULTS: We find significant thickness and volume changes localized to the transentorhinal cortex through high field strength atlasing.

DISCUSSION: This demonstrates that in vivo neuroimaging biomarkers can detect these early changes among subjects with mild cognitive impairment.

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