Dispersive Optical Activity of (R)-Methylene Norbornene: Intrinsic Response and Solvation Effects.

The dispersive optical activity of a homoconjugated bicyclic diene, (R)-methylene norbornene (R-MNB), was interrogated under complementary vapor-phase and solution-phase conditions to elucidate the structural/electronic provenance of its unusual chiroptical signatures and to explore the marked influence of environmental perturbations. The intrinsic (isolated-molecule) values of specific rotation measured at 355 and 633 nm (1623.5 ± 5.5 and 390.4 ± 3.7 deg dm-1 (g/mL)-1 ) were found to be factors of 3.9 and 2.1 smaller in magnitude than analogous quantities obtained for the kindred enone, (R)-norbornenone (R-NBO), reflecting, in part, the loss of prominent magnetic-dipole contributions from the C═O moiety and the exclusion of electron delocalization from the oxygen lone pairs. The wavelength-resolved rotatory powers of R-MNB were enhanced dramatically (by ∼40% on average) upon dissolution in any of the four common solvents targeted by the present study (acetonitrile, di-n-butylether, cyclohexane, and chloroform), yet displayed only a slight dependence on the exact nature of the surrounding liquid (±2.7% variation from the mean at 589.3 nm). Quantum-chemical calculations built upon the linear-response frameworks of density-functional theory and coupled-cluster theory were enlisted to interpret experimental results, with the substantial effects incurred by nonspecific solvation phenomena being explored through use of polarizable continuum models and bulk property-response relationships. Aside from enumerating the varied quality of agreement attained between computational predictions and polarimetric measurements, these efforts have found that refractive-index correlations, akin to those embodied in the venerable (albeit often discounted) Lorentz local-field correction, afford a viable means of linking the chiroptical behavior of R-MNB across phases.