Noninvasive Vascular Modulography Method for Imaging the Local Elasticity of Atherosclerotic Plaques: Simulation and In Vitro Vessel Phantom Study.

Mechanical and morphological characterization of atherosclerotic lesions in carotid arteries remains an essential step for the evaluation of rupture prone plaques and the prevention of strokes. In this paper, we propose a noninvasive vascular imaging modulography (NIV-iMod) method, which is capable of reconstructing a heterogeneous Young's modulus distribution of a carotid plaque from the Von Mises strain elastogram. Elastograms were computed with noninvasive ultrasound images using the Lagrangian speckle model estimator and a dynamic segmentation-optimization procedure to highlight mechanical heterogeneities. This methodology, based on continuum mechanics, was validated in silico with finite-element model strain fields and ultrasound simulations, and in vitro with polyvinyl alcohol cryogel phantoms based on magnetic resonance imaging geometries of carotid plaques. In silico, our results show that the NiV-iMod method: 1) successfully detected and quantified necrotic core inclusions with high positive predictive value (PPV) and sensitivity value (SV) of 81±10% and 91±6%; 2) quantified Young's moduli of necrotic cores, fibrous tissues, and calcium inclusions with mean values of 32±23, 515±30, and 3160±218 kPa (ground true values are 10, 600, and 5000 kPa); and 3) overestimated the cap thickness by . In vitro, the PPV and SV for detecting soft inclusions were 60±21% and 88±9%, and Young's modulus mean values of mimicking lipid, fibrosis, and calcium were 34±19, 193±14, and 649±118 kPa (ground true values are 25±3, 182±21, and 757±87 kPa).