Chemical Constituents and Antifungal Activity of Ficus hirta Vahl. Fruits.

Phytochemical investigation of Ficus hirta Vahl. (Moraceae) fruits led to isolate two carboline alkaloids ( 1 and 2 ), five sesquiterpenoids/norsesquiterpenoids ( 3-7 ), three flavonoids ( 8-10 ), and one phenylpropane-1,2-diol ( 11 ). Their structures were elucidated by the analysis of their 1D and 2D NMR, and HR-ESI-MS data. All of the isolates were isolated from this species for the first time, while compounds 2 , 4-6 , and 8-11 were firstly reported from the genus Ficus . Antifungal assay revealed that compound 8 (namely pinocembrin-7- O -β-d-glucoside), a major flavonoid compound present in the ethanol extract of F. hirta fruits, showed good antifungal activity against Penicillium italicum , the phytopathogen of citrus blue mold caused the majority rotten of citrus fruits.