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A Tale of Two Genes: Microglial Apoe and Trem2.

Anna A Pimenova, Edoardo Marcora, Alison M Goate
Immunity 2017 September 20
Microglial cell function is implicated in the etiology of Alzheimer's disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.

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