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Journal Article
Research Support, Non-U.S. Gov't
Review
Light-sensitive drugs in topical formulations: stability indicating methods and photostabilization strategies.
Future Medicinal Chemistry 2017 October
Photostability tests applied on commercial specialties for topical use have demonstrated a greater vulnerability of several drugs, due to greater exposure to light than other pharmaceutical forms. Photodegradation of a drug can considerably modify its pharmacokinetic behavior by varying the therapeutic index. The evaluation of the degradation profile of a drug, according to the ICH rules, is of primary importance in developing an appropriate topical formulation. Advanced strategies have been proposed to increase the protection from the light of the photolabile drugs. Supramolecular systems have been investigated to improve both pharmacokinetic profile and photostability. In this review, the more recent stability-monitoring methods for the analysis of drugs in topical formulations are collected and the main approaches for the drug photostabilization are discussed.
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