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Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer.
World Journal of Surgical Oncology 2017 September 19
BACKGROUND: Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer. However, it is unclear whether Foxp3 is correlated with lymphangiogenesis of cervical cancer.
METHODS: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.
RESULTS: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.
CONCLUSIONS: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.
TRIAL REGISTRATION: Gunagdong Medical University, PJ2013049.
METHODS: In this experiment, expression of Foxp3 and VEGF-C was detected in 50 cervical cancer samples by immunohistochemistry. In addition, we evaluated the association between Foxp3 and VEGF-C expression and lymphangiogenesis of cervical cancer evaluated by lymphatic vessel density.
RESULTS: These data demonstrate Foxp3 is positively correlated with VEGF-C expression. Furthermore, Foxp3 is associated with lymphangiogenesis of cervical cancer.
CONCLUSIONS: These results revealed Foxp3 play an important role in lymphangiogenesis of cervical cancer.
TRIAL REGISTRATION: Gunagdong Medical University, PJ2013049.
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