Clinical study of vitamin A combined with vitamin B in prevention and treatment of anemia in premature infants.

BACKGROUND: We explored the clinical efficacy of vitamin A combined with vitamin B in the prevention and treatment of premature infants with anemia.

METHODS: One hundred fifty cases of premature infants were divided into three groups. Vitamin A combined with recombinant human erythropoietin (group A), vitamin B combined with recombinant human erythropoietin (group B), vitamin A combined with vitamin B combined with recombinant human erythropoietin treatment (recorded as group C). Levels of serum ferritin (SF), hemoglobin (Hb), hematocrit (Hct) and reticulocyte (Ret) in the serum of children before and after treatment were compared with those of three different treatments.

RESULTS: After treatment, the levels of SF, Hb and Ret in group C were higher than those in group A and B, and the level of Hct in group C was lower than that in group A and B (P<0.05) There was no significant difference in SF, Hb, Hct and Ret between the two groups (P>0.05). The ratio of blood transfusion in group C was lower than that in group A and B (P<0.05). There was no significant difference between the two groups (P>0.05).

CONCLUSIONS: Vitamin A combined with vitamin B can effectively prevent anemia in premature infants, which has important clinical significance.