Establishing age-specific reference intervals for anti-Müllerian hormone in adult Chinese women based on a multicenter population.

AIM OF THIS STUDY: Anti-Müllerian hormone (AMH) is useful for the assessment of ovarian reserve and treatment of individualized in vitro fertilization (IVF). The aim of this study is to establish AMH reference interval for adult Chinese women on the Beckman Beckman DxI 800 platform.

MATERIAL AND METHODS: From May to September 2013, serum from 1169 apparently healthy adult females from five representative cities in China (Beijing, Hangzhou, Guangzhou, Dalian and Urumqi) were collected, and AMH was analyzed on the platform of Beckman DxI 800 automated chemiluminescence immunoassay. Multiple regression analysis was used to investigate the effects of region, sex, age, body mass index (BMI), systolic blood pressure (SBP), exercise on AMH. Age specific reference interval for AMH was established.

RESULTS: The main factor affecting AMH levels was age (B=-0.756, P<0.001). The AMH reference intervals for adult Chinese women aged 19-24years, 25-29years, 30-34years, 35-39years, 40-44years, 45-49years and ≥50years were 0.74-16.06, 0.67-11.64, 0.50-9.99, 0.09-8.33, 0.04-4.09, 0.01-1.46 and <0.01-0.18ng/ml, respectively. The linear, quadratic and cubic models could either provide good fit regression model to describe the decline of AMH with age (R2 =0.40).

CONCLUSION: This study firstly established age-specific reference intervals for AMH in Chinese women based on multicenter population.