Sequential molecule-triggered-release system based on acetylated amylose helix aggregates.

We developed a novel sequential molecule-triggered-release system based on acetylated amylose helix aggregates with a proper degree of substitution, in which a loaded molecule can be trigger-released by trigger molecules in sequence. The system is sensitive and capable of time-controllable triggered release. The mechanism involves the sequential pushing of wrapped molecules with low binding free energy out of the helix cavity by a triggered molecule with a high binding free energy.