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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Transformation of the B Ring to the C Ring of Bryostatins by Csp 3 -H Amination and Z to E Isomerization.
Organic Letters 2017 October 7
An interesting approach to transform the B ring of bryostatins to the C ring has been developed. The key tactics of the approach feature an intramolecular Csp3 -H bond amination to form spirocyclic hemiaminal, which undergoes ring opening to afford the C ring found in bryostatin 17. The subsequent epoxidation/oxidation sequence results in Z to E isomerization of the exo-cyclic enoate, delivering the common precursor, which could be transformed into the C ring found in bryostatins 1, 2, 4-9, 12, 14, and 15.
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