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No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8 + TILs.

Will Bailis, Justin A Shyer, Michael Chiorazzi, Richard A Flavell
Cancer Cell 2017 September 12
The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8+ TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

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