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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Multivariate Metal-Organic Frameworks for Dialing-in the Binding and Programming the Release of Drug Molecules.
Journal of the American Chemical Society 2017 October 12
We report the control of guest release profiles by dialing-in desirable interactions between guest molecules and pores in metal-organic frameworks (MOFs). The interactions can be derived by the rate constants that were quantitatively correlated with the type of functional group and its proportion in the porous structure; thus the release of guest molecules can be predicted and programmed. Specifically, three probe molecules (ibuprofen, rhodamine B, and doxorubicin) were studied in a series of robust and mesoporous MOFs with multiple functional groups [MIL-101(Fe)-(NH2 )x , MIL-101(Fe)-(C4 H4 )x , and MIL-101(Fe)-(C4 H4 )x (NH2 )1-x ]. The release rate can be adjusted by 32-fold [rhodamine from MIL-101(Fe)-(NH2 )x ], and the time of release peak can be shifted by up to 12 days over a 40-day release period [doxorubicin from MIL-101(Fe)-(C4 H4 )x (NH2 )1-x ], which was not obtained in the physical mixture of the single component MOF counterparts nor in other porous materials. The corelease of two pro-drug molecules (ibuprofen and doxorubicin) was also achieved.
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