The association of Mullerian anomalies and placenta abruption: a meta-analysis.

BACKGROUND: Several epidemiological studies have determined that Mullerian anomalies can increase the risk of placenta abruption. To date, no meta-analysis has been performed for assessing the relationship between placenta abruption and Mullerian anomalies. This meta-analysis was conducted to estimate the association between placenta abruption and Mullerian anomalies.

METHODS: We conducted a computerized literature search in Pubmed, Scopus and Web of Science covering the search period until August 2017. Heterogeneity was recognized by Chi-squared test and the I2 statistic. The Egger's and Begg's tests were examined for the possibility of publication bias. We carried out a meta-analysis to obtain a summary measure of the association between of placenta abruption and Mullerian anomalies using a random-effects model.

RESULTS: A total of 732 studies was search with 653,146 participants. The overall estimate of OR was 3.10 (95% CI: 1.47, 4.74).

CONCLUSIONS: We reported based on odds ratio reports in epidemiological studies that Mullerian anomalies are a risk factor for placenta abruption.