We have located links that may give you full text access.
Temperature effects on accommodative processes in simulated amyotrophic lateral sclerosis in the physiological range.
The present study investigates the temperature dependence of electrotonic potentials in mathematically-simulated myelinated axons with one of three increasingly-severe type of amyotrophic lateral sclerosis (ALS) pathology, termed as ALS1, ALS2 and ALS3, respectively, in the physiological range (30-37∘C). These potentials were elicited by long-lasting (100 ms) subthreshold polarizing current stimuli (±40% of the threshold). Numerical solutions were computed using our temperature-dependent multi-layered model. The results showed the following trends: (i) in ALS1, polarizing electrotonic potentials were normal; (ii) in ALS2 and ALS3, action potentials were elicited in the early parts of the depolarizing electrotonic potentials, and (iii) in ALS3, spontaneous discharges were elicited after the termination of applied hyperpolarizing stimuli (i.e., post-anodal excitation). The ionic currents underlying electrotonic potentials in the ALS1 case were attributable to the activation of potassium fast (Kf+) and slow (Ks+) channels in the nodal and internodal axolemma beneath the myelin sheath. By contrast, in ALS2 and ALS3, the depolarizing stimuli activated the classical "transient" Na+ channels in the nodal and internodal axolemma beneath the myelin sheath eliciting action potential generation. These results obtained were closer to those observed in hypothermia (⩽25∘C) than in hyperthermia (⩾40∘C).
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app