Encephalopathy in Henoch-Schönlein Purpura.

BACKGROUND: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood. Severe central nervous system (CNS) involvement is rare in HSP.

CASE CHARACTERISTICS: Three children with features of HSP presented with seizures and CNS dysfunction.

OBSERVATION: All three children had abnormalities on neuroimaging; 2 had complete remission but one was left with severe neurological damage.

MESSAGE: HSP patients may rarely present with CNS involvement with a prolonged course requiring aggressive treatment.