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JOURNAL ARTICLE

Immune checkpoint molecule PD-1 acts as a novel biomarker for the pathological process of gestational diabetes mellitus

Xiaoying Ye, Songwen Ju, Houquan Duan, Yongliang Yao, Jianfen Wu, Shao Zhong, Lei Chen, ShaSha Cao, Yongfang Xu, Xiaocui Zheng, Haiyan Wang, Yan Ge, Songguang Ju
Biomarkers in Medicine 2017 September 11
28891298

AIM: Accumulating evidence suggested that challenge of the maternal-fetal interaction during pregnancy might cause the impairment of immunological hemostasis and lead to gestational diabetes mellitus (GDM) pathological process. Immune checkpoint molecule PD-1 is one of the critical molecule balancing immune response and immunological tolerance.

METHODS: PD-1 expressions on T-cell subsets of GDM patients and control groups were measured via flow cytometric analysis and followed up.

RESULTS: Downregulation of PD-1 acted as an indicator for GDM occurrence in the third trimester of pregnancy. With the recovery of GDM, PD-1 expression restored to normal level.

CONCLUSION: PD-1 expression on T-cell subsets is a novel biomarker for the occurrence and recovery of GDM.

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