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To predict the radiosensitivity of nasopharyngeal carcinoma using intravoxel incoherent motion MRI at 3.0 T.

Oncotarget 2017 August 9
PURPOSE: To investigate intravoxel incoherent motion (IVIM) MRI for evaluating the sensitivity of radiotherapy on nasopharyngeal carcinoma (NPC).

RESULTS: The reproducibility between intra-observer and inter-observer was relatively good. D (0.72×10-3 mm2 /s±0.14 vs . 0.54×10-3 mm2 /s±0.23; P < 0.001) and D * (157.92×10-3 mm2 /s±15.21 vs . 120.36×10-3 mm2 /s±10.22; P < 0.0001) were significantly higher in effective group than poor-effective group, whereas the difference of f (18.79%±2.51 vs . 16.47%±1.51) and ADC (1.21×10-3 mm2 /s±0.11 vs . 1.33×10-3 mm2 /s±0.23) could not reach statistical significant between the 2 groups ( P > 0.05).

CONCLUSIONS: IVIM may be potentially useful in assessing the radiosensitivity of NPC. The higher D value combining with higher D * value might indicate the more radiosensitive of NPC, and increased D * might reflect increased blood vessel generation and parenchymal perfusion in NPC.

MATERIALS AND METHODS: Sixty consecutive patients (20 female, range, 27-83 years, mean age, 52 years) newly diagnosed NPC in the stage of T3 or T4 were enrolled. Forty-two of them were divided into effective group clinically after a standard radiotherapy according to the RECIST criteria. IVIM with 13 b-values (range, 0-800 s/mm2 ) and general MRI were performed at 3.0T MR scanner before and after radiotherapy. The parameters of IVIM including perfusion fraction ( f ), perfusion-related diffusion ( D *), pure molecular diffusion ( D ) and apparent diffusion coefficient ( ADC ) were calculated. Two radiologists major in MRI diagnose analyzed all images independently and placed regions of interest (ROIs). Intra-class correlation coefficient (ICC) was used to evaluate intra-observer and inter-observer agreement. And Mann-Whitney test was used to assess the differences between the two groups.

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