Xanthones isolated from Gentianella acuta and their protective effects against H 2 O 2 -induced myocardial cell injury.

In the present study, two new xanthones, (5'S,8'S)-1,3,5,8-tetrahydroxyxanthone(7→2')-1,3,5,8-tetrahydroxy-5',6',7',8'-tetrahydroxanthone (1), 5-hydroxy-3,4,6-trimethoxyxanthone-1-O-β-D-glucopyranoside (2), and eight known xanthones (3-10) were isolated from the whole plants of Gentianella acuta. Their structures were identified by the spectroscopic analyses (HR-ESI-MS, and 1D and 2D NMR). Meanwhile, cell-protective effects against H2 O2 -induced H9c2 cardiomyocyte injury and cytotoxic activities of compounds 1-10 were also determined.