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SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer.

Amrita M Nargund, Hatice U Osmanbeyoglu, Emily H Cheng, James J Hsieh
Molecular & Cellular Oncology 2017
Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

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