Serum antimüllerian hormone levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer.

OBJECTIVE: To investigate whether serum antimüllerian hormone (AMH) levels are independently related to miscarriage rates after in vitro fertilization-embryo transfer (IVF-ET).

DESIGN: Cohort study.

SETTING: University-affiliated IVF-ET center.

PATIENT(S): A total of 1,060 patients who attained a clinical pregnancy after IVF-ET.

INTERVENTIONS(S): Centralized serum AMH measurements were performed within the 12 months before IVF-ET. Binary logistic regression was used to verify whether serum AMH levels were associated with the occurrence of a miscarriage independently from confounding factors, such as age and intensity of ovarian response to controlled ovarian stimulation assessed by the number of oocytes retrieved.

MAIN OUTCOME MEASURE(S): Miscarriage rates.

RESULT(S): In patients displaying reduced serum AMH levels, miscarriage rates were significantly increased independently from age and the number of oocytes retrieved.

CONCLUSION(S): The present data indicate that serum AMH levels are independently associated with the occurrence of a miscarriage after IVF-ET.