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CASE REPORTS
JOURNAL ARTICLE
REVIEW
Refractory LCH With Secondary Intracranial PNET: A Case Report and Review of Literature.
Journal of Pediatric Hematology/oncology 2018 March
The occurrence of second malignant neoplasms in patients with Langerhans cell histiocytosis is infrequent but has been reported. Here we report the case of a child with refractory Langerhans cell histiocytosis who was treated with cladribine and later developed a secondary intracranial primitive neuroectodermal tumor. The possible association of cladribine with second neoplasm is further discussed.
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