Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.

AIMS: We investigated the association between ubiquitin-conjugating enzyme E2Z (UBE2Z) gene SNP rs46522 and the risk of CAD in a Chinese Han population with type 2 diabetes and explored a possible interactive effect with environmental risk factors of CAD.

METHODS: 665 patients with T2D were enrolled; 390 were CAD patients and 275 were non-CAD patients. Genotype analysis of rs46522 (T>C) was performed using PCR-RFLP.

RESULTS: The SNP rs47522 was associated with the risk of CAD supposing recessive inheritance model (TT versus CC+CT, OR' = 1.277, 95%CI' 1.039-1.570, p ' = 0.020) and codominant model (TT versus CT, OR' = 1.673, 95%CI' 1.088-2.570, p ' = 0.019) after adjustment for confounders of CAD. A synergistic effect of rs46522 and BMI was discovered ( β = 0.012, p for interreaction  = 0.028). In subgroup analysis, minor allele T was significantly associated with CAD in overweight and obesity subgroup ( p = 0.034), and the association was also proved in recessive model (OR = 1.537, 95%CI 1.075-2.196, p = 0.018). Smokers with genotype TT had threefold risk of CAD in comparison to nonsmokers with genotype TC or CC ( p < 0.001).

CONCLUSIONS: The SNP rs46522 in UBE2Z gene is associated with the risk of CAD in the individuals of Chinese Han descent with type 2 diabetes and is of synergistic effect with BMI.